Salmona Petersen, Mario

publicaciones seleccionadas

• artículo editorial

  • A Comprehensive Technology Platform for the Rapid Discovery of Peptide Inhibitors against SARS-CoV-2 Pseudovirus Infection.  International Journal of Molecular Sciences.  2023
  • Effect of Non-Nutritive Sweeteners on the Gut Microbiota.  Nutrients.  2023
  • Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents.  Nanomaterials.  2023
  • Alzheimer’s Disease Prevention through Natural Compounds: Cell-Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity.  ACS Chemical Neuroscience.  2022
  • Cytoskeleton Elements Contribute to Prion Peptide-Induced Endothelial Barrier Breakdown in a Blood–Brain Barrier In Vitro System.  International Journal of Molecular Sciences.  2022
  • Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis.  International Journal of Molecular Sciences.  2022
  • Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice.  Nanomaterials.  2022
  • Apelin Resistance Contributes to Muscle Loss during Cancer Cachexia in Mice.  Cancers.  2022
  • Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin.  Proceedings of the National Academy of Sciences.  2021
  • Nonphosphorylated tau slows down Aβ1–42 aggregation, binds to Aβ1–42 oligomers, and reduces Aβ1–42 toxicity.  Journal of Biological Chemistry.  2021
  • A portable optical-fibre-based surface plasmon resonance biosensor for the detection of therapeutic antibodies in human serum.  Scientific Reports.  2020
  • Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington's Disease.  ACS Chemical Neuroscience.  2020
  • Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease.  Molecular Nutrition and Food Research.  2020
  • Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1–42-mediated toxicity.  Neurobiology of Disease.  2020
  • Quantitative analysis of proteins which are members of the same protein complex but cause locus heterogeneity in disease.  Scientific Reports.  2020
  • Sleep inhibition induced by amyloid-β oligomers is mediated by the cellular prion protein.  Journal of Sleep Research.  2020
  • Synthesis and molecular modelling studies of new 1,3-diaryl-5-oxo-proline derivatives as endothelin receptor ligands.  Molecules.  2020
  • A Surface Plasmon Resonance-based assay to measure serum concentrations of therapeutic antibodies and anti-drug antibodies.  Scientific Reports.  2019
  • Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model.  ACS Nano.  2019
  • Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants.  Biochimica et Biophysica Acta - General Subjects.  2019
  • Monitoring the fate of orally administered plga nanoformulation for local delivery of therapeutic drugs.  Pharmaceutics.  2019
  • Plasma and brain concentrations of doxycycline _after single and repeated doses in wild-type and APP23 mice^s.  Journal of Pharmacology and Experimental Therapeutics.  2019
  • Review: PrP 106-126 – 25 years after.  Neuropathology and Applied Neurobiology.  2019
  • Super Resolution Microscopy of SUMO Proteins in Neurons.  Frontiers in Cellular Neuroscience.  2019
  • The anti-amyloidogenic action of doxycycline: A molecular dynamics study on the interaction with Aβ42.  International Journal of Molecular Sciences.  2019
  • [1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor.  European Journal of Medicinal Chemistry.  2019
  • bioNMR-based identification of natural anti-Aβ compounds in Peucedanum ostruthium.  Bioorganic Chemistry.  2019
  • p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation.  Laboratory Investigation.  2019
  • Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models.  Neurobiology of Aging.  2018
  • In Situ Tissue Labeling of Cerebral Amyloid Using HIV-Related Tat Peptide.  Molecular Neurobiology.  2018
  • Mutagenicity, anticancer activity and blood brain barrier: similarity and dissimilarity of molecular alerts.  Toxicology Mechanisms and Methods.  2018
  • NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts.  Food Chemistry.  2018
  • Realistic Evaluation of Titanium Dioxide Nanoparticle Exposure in Chewing Gum.  Journal of Agricultural and Food Chemistry.  2018
  • Safety and Toxicology of Magnolol and Honokiol.  Planta Medica.  2018
  • Translational Research in Alzheimer's and Prion Diseases.  Journal of Alzheimer's Disease.  2018
  • Use of quasi-SMILES to model biological activity of “micelle–polymer” samples.  Structural Chemistry.  2018
  • V363I and V363A mutated tau affect aggregation and neuronal dysfunction differently in C. elegans.  Neurobiology of Disease.  2018
  • A simple headspace gas chromatography/mass spectrometry method for the quantitative determination of the release of the antioxidants butylated hydroxyanisole and butylated hydroxytoluene from chewing gum.  Rapid Communications in Mass Spectrometry.  2017
  • Applicability of [¹¹C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model.  Neurobiology of Aging.  2017
  • Biocompatible Polymer Nanoformulation to Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.  Molecular Pharmaceutics.  2017
  • Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.  Antioxidants and Redox Signaling.  2017
  • Flavonoids and Their Glycosides as Anti-amyloidogenic Compounds: Aβ1–42 Interaction Studies to Gain New Insights into Their Potential for Alzheimer's Disease Prevention and Therapy.  Chemistry - An Asian Journal.  2017
  • HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders.  Scientific Reports.  2017
  • Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.  Journal of Alzheimer's Disease.  2017
  • Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles.  ACS Nano.  2017
  • Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry.  ACS Chemical Neuroscience.  2017
  • Multifunctional LUV liposomes decorated for BBB and amyloid targeting. A. In vitro proof-of-concept.  European Journal of Pharmaceutical Sciences.  2017
  • New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7and 5-HT1Areceptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies.  Bioorganic and Medicinal Chemistry.  2017
  • Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction.  Biophysical Chemistry.  2017
  • QSAR model for blood-brain barrier permeation.  Journal of Pharmacological and Toxicological Methods.  2017
  • Single particle extinction and scattering optical method unveils in real time the influence of the blood components on polymeric nanoparticles.  Nanomedicine: Nanotechnology, Biology, and Medicine.  2017
  • The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study.  Scientific Reports.  2017
  • Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer's disease.  Brain, Behavior, and Immunity.  2017
  • Utilization of the monte carlo method to build up QSAR models for hemolysis and cytotoxicity of antimicrobial peptides.  Current Drug Discovery Technologies.  2017
  • Amyloidβ Peptides in interaction with raft-mime model membranes: A neutron reflectivity insight.  Scientific Reports.  2016
  • An early developmental vertebrate model for nanomaterial safety: Bridging cell-based and mammalian toxicity assessment.  Nanomedicine.  2016
  • Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.  Aging Cell.  2016
  • Cellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17.  Scientific Reports.  2016
  • Clusterin binds to Aβ1-42 Oligomers with high affinity and interferes with peptide aggregation by inhibiting primary and secondary nucleation.  Journal of Biological Chemistry.  2016
  • Copper(II) ions affect the gating dynamics of the 20S proteasome: A molecular and in cell study.  Scientific Reports.  2016
  • Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.  Bioorganic and Medicinal Chemistry Letters.  2016
  • Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer.  Biomacromolecules.  2016
  • Internalization of nanopolymeric tracers does not alter characteristics of placental cells.  Journal of Cellular and Molecular Medicine.  2016
  • Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds.  Toxicology Letters.  2016
  • Pulmonary administration of functionalized nanoparticles significantly reduces beta-amyloid in the brain of an Alzheimer’s disease murine model.  Nano Research.  2016
  • Role of Nrf2, HO-1 and GSH in neuroblastoma cell resistance to bortezomib.  PLoS ONE.  2016
  • Structural Modifications of cis-Glycofused Benzopyran Compounds and Their Influence on the Binding to Amyloid-β Peptide.  Chemistry - An Asian Journal.  2016
  • Synthesis and Preliminary Biological Evaluation of Fluorescent Glycofused Tricyclic Derivatives of Amyloid β-Peptide Ligands.  European Journal of Organic Chemistry.  2016
  • Tackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β.  Scientific Reports.  2016
  • The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers.  Journal of Alzheimer's Disease.  2016
  • The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt.  Neurobiology of Disease.  2016
  • The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease.  Nanomedicine: Nanotechnology, Biology, and Medicine.  2016
  • The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.  Neurobiology of Disease.  2016
  • Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria.  Scientific Reports.  2015
  • Investigation of Functionalized Poly(N,N-dimethylacrylamide)-block-polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood-Brain Barrier in Vitro.  Macromolecular Bioscience.  2015
  • Longitudinal tracking of triple labeled umbilical cord derived mesenchymal stromal cells in a mouse model of Amyotrophic Lateral Sclerosis.  Stem Cell Research.  2015
  • Multigram synthesis and in Vivo efficacy studies of a novel multitarget anti-alzheimer's compound.  Molecules.  2015
  • NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease.  Bioorganic and Medicinal Chemistry.  2015
  • Organ distribution and bone tropism of cellulose nanocrystals in living mice.  Biomacromolecules.  2015
  • Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands.  Bioorganic and Medicinal Chemistry Letters.  2015
  • A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis.  Blood.  2014
  • A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma.  Nanotechnology.  2014
  • A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma.  Sensors (Basel, Switzerland).  2014
  • An integrated approach for the systematic evaluation of polymeric nanoparticles in healthy and diseased organisms.  Journal of Nanoparticle Research.  2014
  • Blood protein coating of gold nanoparticles as potential tool for organ targeting.  Biomaterials.  2014
  • Cis-glyco-fused benzopyran derivatives as hit compounds for the development of therapeutic and diagnostic tools against neurodegenerative diseases.  ChemPlusChem.  2014
  • Determination of tissue levels of a neuroprotectant drug: The cell permeable JNK inhibitor peptide.  Journal of Pharmacological and Toxicological Methods.  2014
  • Different mutations at V363 MAPT codon are associated with atypical clinical phenotypes and show unusual structural and functional features.  Neurobiology of Aging.  2014
  • Doxycycline in Creutzfeldt-Jakob disease: A phase 2, randomised, double-blind, placebo-controlled trial.  The Lancet Neurology.  2014
  • Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity.  Neurobiology of Disease.  2014
  • In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [¹⁸F]flutemetamol.  EJNMMI Research.  2014
  • In vivo fate of avidin-nucleic acid nanoassemblies as multifunctional diagnostic tools.  ACS Nano.  2014
  • Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles.  Nanotechnology.  2014
  • Mono and dually decorated nanoliposomes for brain targeting, in vitro and in vivo studies.  Pharmaceutical Research.  2014
  • Monomeric Aβ1-42 and RAGE: Key players in neuronal differentiation.  Neurobiology of Aging.  2014
  • Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in alzheimer’s disease mouse models.  Journal of Neuroscience.  2014
  • Natural compounds against neurodegenerative diseases: Molecular characterization of the interaction of catechins from green tea with Aβ1-42, PrP106-126, and ataxin-3 oligomers.  Chemistry - A European Journal.  2014
  • Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.  Neurobiology of Disease.  2014
  • Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands.  European Journal of Medicinal Chemistry.  2014
  • Synthesis and evaluation of a ¹⁸F-curcumin derivate for β-amyloid plaque imaging.  Bioorganic and Medicinal Chemistry.  2014
  • Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: Synthesis, biological characterization, and behavioral studies.  Journal of Medicinal Chemistry.  2014
  • The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly.  Journal of Biological Chemistry.  2014
  • c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo..  Cell death & disease.  2014
  • A new face for old antibiotics: Tetracyclines in treatment of amyloidoses.  Journal of Medicinal Chemistry.  2013
  • Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.  Amyloid.  2013
  • Biocompatible fluorescent nanoparticles for in vivo stem cell tracking.  Nanotechnology.  2013
  • Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease.  Pure and Applied Chemistry.  2013
  • Functionalization with TAT-peptide enhances blood-brain barrier crossing in vitro of nanoliposomes carrying a curcumin-derivative to bind amyloid-β peptide.  Journal of Nanomedicine and Nanotechnology.  2013
  • Longitudinal amyloid imaging in mouse brain with ¹¹C-PIB: Comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease.  Journal of Nuclear Medicine.  2013
  • Novel approaches for studying amyloidogenic peptides/proteins.  Current Opinion in Pharmacology.  2013
  • Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit.  PLoS ONE.  2013
  • PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors.  PLoS ONE.  2013
  • Soluble Aβ oligomer-induced synaptopathy: C-Jun N-terminal kinase's role.  Journal of Molecular Cell Biology.  2013
  • Applications of Surface Plasmon Resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes.  Sensors (Switzerland).  2012
  • Blood-brain barrier alterations in the cerebral cortex in experimental autoimmune encephalomyelitis.  Journal of Neuropathology and Experimental Neurology.  2012
  • C. elegans Expressing Human β2-Microglobulin: A Novel Model for Studying the Relationship between the Molecular Assembly and the Toxic Phenotype.  PLoS ONE.  2012
  • Colloidal stability of polymeric nanoparticles in biological fluids.  Journal of Nanoparticle Research.  2012
  • Good gene, bad gene: New APP variant may be both.  Progress in Neurobiology.  2012
  • Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.  Journal of Medicinal Chemistry.  2012
  • In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.  PLoS ONE.  2012
  • Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease.  PLoS ONE.  2012
  • New mutations in MAPT gene causing frontotemporal lobar degeneration: Biochemical and structural characterization.  Neurobiology of Aging.  2012
  • Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans.  Journal of Biological Chemistry.  2012
  • β-Amyloid 1-42 induces physiological transcriptional regulation of BACE1.  Journal of neurochemistry.  2012
  • A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)1-40 and Aβ1-42 from the corresponding depsipeptides.  Analytical Biochemistry.  2011
  • Cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands.  Chemical Communications.  2011
  • Curcumin derivatives as new ligands of Aβ peptides.  Journal of Biotechnology.  2011
  • Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide.  Biomaterials.  2011
  • Effect of tetracyclines on the dynamics of formation and destructuration of β2-microglobulin amyloid fibrils.  Journal of Biological Chemistry.  2011
  • Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction.  PLoS ONE.  2011
  • Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model.  Nanomedicine: Nanotechnology, Biology, and Medicine.  2011
  • Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: Coordinated cell killing and remodeling of intercellular junctions.  Journal of neurochemistry.  2011
  • Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.  Organic and Biomolecular Chemistry.  2011
  • Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction.  Organic and Biomolecular Chemistry.  2011
  • The binding affinity of anti-Aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue.  Biomaterials.  2011
  • The molecular assembly of amyloid Aβ controls its neurotoxicity and binding to cellular proteins.  PLoS ONE.  2011
  • Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ1-42 peptide, synthesized by depsi-peptide technique.  Biosensors and Bioelectronics.  2011
  • A new fluorogenic peptide determines proteasome activity in single cells.  Journal of Medicinal Chemistry.  2010
  • Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide.  Journal of Biotechnology.  2010
  • Lipid-based nanoparticles with high binding affinity for amyloid-β1-42 peptide.  Biomaterials.  2010
  • Mutant prion protein expression is associated with an alteration of the rab GDP dissociation inhibitor α (GDI)/rab11 pathway.  Molecular and Cellular Proteomics.  2010
  • Nanoparticles against Alzheimer's disease: PEG-PACA nanoparticles are able to link the aβ-peptide and influence its aggregation kinetic..  Journal of controlled release : official journal of the Controlled Release Society.  2010
  • Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features.  Acta Neuropathologica.  2010
  • New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide.  Analytical chemistry.  2010
  • Polyunsaturated fatty acids protect against prion-mediated synapse damage in vitro..  Neurotoxicity Research.  2010
  • Solid-state stability studies of cholecystokinin (CCK-4) peptide under nonisothermal conditions using thermal analysis, chromatography and mass spectrometry.  European Journal of Pharmaceutical Sciences.  2010
  • Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein.  Proceedings of the National Academy of Sciences of the United States of America.  2010
  • Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers.  Neurobiology of Disease.  2010
  • A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.  science.  2009
  • Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process.  Molecular and Cellular Neuroscience.  2009
  • Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.  PLoS ONE.  2009
  • Glimepiride reduces the expression of PrP^c, prevents prp^sc formation and protects against prion mediated neurotoxicity.  PLoS ONE.  2009
  • JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.  Neurobiology of Disease.  2009
  • Overcoming synthetic Aβ peptide aging: A new approach to an age-old problem.  Amyloid.  2009
  • Proteomic profiling of cervical and lumbar spinal cord reveals potential protective mechanisms in the Wobbler mouse, a model of motor neuron degeneration.  Journal of Proteome Research.  2009
  • ST1859 reduces prion infectivity and increase survival in experimental scrapie..  Archives of virology.  2009
  • Spontaneous β-helical fold in prion protein: The case of PrP(82-146).  Proteins: Structure, Function and Bioinformatics.  2009
  • Tetracyclines and prion infectivity.  Infectious Disorders - Drug Targets.  2009
  • The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide.  Journal of neurochemistry.  2009
  • c-Jun N-terminal kinase binding domain-dependent phosphorylation of mitogen-activated protein kinase kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways in cortical neurons.  Neuroscience.  2009
  • Conformational Plasticity of the Gerstmann-Sträussler-Scheinker Disease Peptide as Indicated by Its Multiple Aggregation Pathways.  Journal of Molecular Biology.  2008
  • Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Aβ1-42.  Neuropharmacology.  2008
  • Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.  BMC Biology.  2008
  • The anti-fibrillogenic activity of tetracyclines on PrP 106-126: A 3D-QSAR study.  Journal of Molecular Modeling.  2008
  • The efficacy of tetracyclines in peripheral and intracerebral prion infection.  PLoS ONE.  2008
  • Cytoplasmic domain of human myelin protein zero likely folded as β-structure in compact myelin.  Biophysical Journal.  2007
  • Cytoplasmic domain of zebrafish myelin protein zero: Adhesive role depends on β-conformation.  Biophysical Journal.  2007
  • Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein.  Journal of Neuroscience.  2007
  • Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse.  Biochemical and Biophysical Research Communications.  2007
  • Acetylcholinesterase triggers the aggregation of PrP 106-126.  Biochemical and Biophysical Research Communications.  2006
  • Aggregation/fibrillogenesis of recombinant human prion protein and Gerstmann-Sträussler-Scheinker disease peptides in the presence of metal ions.  Biochemistry.  2006
  • Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity.  Proteomics.  2006
  • Conformational polymorphism of the PrP106-126 peptide in different environments: A molecular dynamics study.  Journal of Physical Chemistry B.  2006
  • Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation.  Journal of Molecular Neuroscience.  2006
  • Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.  Journal of Biological Chemistry.  2006
  • Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.  Journal of Biological Chemistry.  2006
  • Gα13 mediates activation of the cytosolic phospholipase A2α through fine regulation of ERK phosphorylation.  Cellular signalling.  2006
  • Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice.  Journal of Biological Chemistry.  2006
  • Redox regulation of cyclophilin A by glutathionylation.  Proteomics.  2006
  • Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: Possible multifunctional role in the pathogenesis.  Journal of Biological Chemistry.  2005
  • Role of plasminogen in propagation of scrapie.  Journal of Virology.  2005
  • Tetracycline and its analogues as inhibitors of amyloid fibrils: Searching for a geometrical pharmacophore by theoretical investigation of their conformational behavior in aqueous solution.  Journal of Molecular Modeling.  2005
  • The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.  Molecular and Cellular Neuroscience.  2005
  • An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds.  Analytical Biochemistry.  2004
  • Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β 1-42.  Journal of Neuroinflammation.  2004
  • Regulation and biochemistry of mouse molybdo-flavoenzymes: The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase.  Journal of Biological Chemistry.  2004
  • Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity.  Journal of Biological Chemistry.  2004
  • The aldehyde oxidase gene cluster in mice and rats: Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.  Journal of Biological Chemistry.  2004
  • The role of platelet activating factor in prion and amyloid-β neurotoxicity.  NeuroReport.  2004
  • Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients.  American Journal of Physiology - Cell Physiology.  2003
  • Evaluation of quinacrine treatment for prion diseases.  Journal of Virology.  2003
  • In vitro Evaluation of the Anti-prionic Activity of Newly Synthesized Congo Red Derivatives.  Arzneimittel-Forschung/Drug Research.  2003
  • Quinacrine Blocks PrP (106-126)-Formed Channels.  Journal of Neuroscience Research.  2003
  • Structural Properties of Gerstmann-Sträussler-Scheinker Disease Amyloid Protein.  Journal of Biological Chemistry.  2003
  • Therapeutic approaches to prion diseases.  Clinics in Laboratory Medicine.  2003
  • Characterization of antimalarial SPf66 peptide using MALDI-TOF MS, CD and SEC.  Peptides.  2002
  • Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems.  Proceedings of the National Academy of Sciences of the United States of America.  2002
  • Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes.  Proceedings of the National Academy of Sciences of the United States of America.  2002
  • Synthetic miniprion PrP106.  Journal of Biological Chemistry.  2002
  • Tetracyclines affect prion infectivity.  Proceedings of the National Academy of Sciences of the United States of America.  2002
  • Wax esters of n-3 polyunsaturated fatty acids: A new stable formulation as a potential food supplement. 1 - Digestion and absorption in rats.  LWT - Food Science and Technology.  2002
  • A 7-kDa Prion Protein (PrP) Fragment, an Integral Component of the PrP Region Required for Infectivity, Is the Major Amyloid Protein in Gerstmann-Sträussler-Scheinker Disease A117V.  Journal of Biological Chemistry.  2001
  • Anti-amyloidogenic activity of tetracyclines: Studies in vitro.  FEBS Letters.  2001
  • Endotoxin regulates the maturation of sterol regulatory element binding protein-1 through the induction of cytokines.  European Cytokine Network.  2001
  • In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products.  Arteriosclerosis, Thrombosis, and Vascular Biology.  2001
  • Purification of the Aldehyde Oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes: Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1.  Journal of Biological Chemistry.  2001
  • Studies on peptide fragments of prion proteins.  Advances in Protein Chemistry.  2001
  • The Stimulation of Inducible Nitric-oxide Synthase by the Prion Protein Fragment 106-126 in Human Microglia is Tumor Necrosis Factor-α-dependent and Involves p38 Mitogen-activated Protein Kinase.  Journal of Biological Chemistry.  2001
  • Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in cerebellar granule cells treated with the prion protein fragment 106-126.  Neurobiology of Disease.  2000
  • Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase.  Journal of Biological Chemistry.  2000
  • Comment on: Neurotoxicity of prion peptide 106-126 not confirmed, by Beat Kunz, Erika Sandmeier, Philipp Christen. (multiple letters) [1].  FEBS Letters.  2000
  • Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production.  Cytokine.  2000
  • Inhibition of monocyte chemotactic protein-1 sysnthesis by statins.  Laboratory Investigation.  2000
  • Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.  International Journal of Developmental Neuroscience.  2000
  • Measurement of intracellular calcium levels by the fluorescent Ca²⁺ indicator Calcium-Green.  Brain Research Protocols.  2000
  • NegriWeb: The website of the Istituto di Ricerche Farmacologiche 'Mario Negri',NegriWeb: Il sito dell'Istituto di Ricerche Farmacologiche 'Mario Negri'.  Ricerca e Pratica.  2000
  • Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro.  Journal of Molecular Biology.  2000
  • A βPP peptide carboxyl-terminal to Aβ is neurotoxic.  American Journal of Pathology.  1999
  • Activation of microglial cells by PrP and β-amyloid fragments raises intracellular calcium through L-type voltage sensitive calcium channels.  Brain Research.  1999
  • Alteration of SREBP activation in liver of trisomy 21 fetuses.  Biochemical and Biophysical Research Communications.  1999
  • Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis.  Biochemical Journal.  1999
  • Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): A depot IL-1ra.  European Journal of Immunology.  1999
  • CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid.  Nature.  1999
  • Determination of solution conformations of PrP106-126, a neurotoxic fragment of prion protein, by ¹H NMR and restrained molecular dynamics.  European Journal of Biochemistry.  1999
  • Erratum: Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure (Journal of Biological Chemistry (1999) 274 (17705- 17710)).  Journal of Biological Chemistry.  1999
  • Influence of mutations associated with familial prion-related encephalopathies on biological activity of prion protein peptides.  Annals of Neurology.  1999
  • Localization and age-dependent expression of the inward rectifier K⁺ channel subunit Kir 5.1 in a mammalian reproductive system.  FEBS Letters.  1999
  • Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines.  NeuroReport.  1999
  • Molecular cloning and functional characterization of brefeldin A-ADP- ribosylated substrate: A novel protein involved in the maintenance of the golgi structure.  Journal of Biological Chemistry.  1999
  • Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126.  Biochemical Journal.  1999
  • Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity.  FEBS Letters.  1999
  • Inhibition of cancer cell growth and c-Myc transcriptional activity by a c-Myc helix 1-type peptide fused to an internalization sequence.  Cancer Research.  1998
  • Modulation of TNF production in a rat mast cell line (RBL) and monocytes (THP-1) by cAMP and glucocorticoids.  International Journal of Immunopathology and Pharmacology.  1998
  • Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line.  Journal of Neuroscience Research.  1998
  • Rapid solid-phase extraction method for automated gas chromatographic- mass spectrometric determination of nicotine in plasma.  Journal of Chromatography B: Biomedical Applications.  1998
  • A neurotoxic and gliotrophic fragment of the prion protein increases plasma membrane microviscosity.  Neurobiology of Disease.  1997
  • Amidation of β-amyloid peptide strongly reduced the amyloidogenic activity without alteration of the neurotoxicity.  Journal of neurochemistry.  1997
  • Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor.  Mediators of inflammation.  1997
  • Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.  science.  1997
  • Identification of a short sequence highly divergent between β- adrenergic-receptor kinases 1 and 2 that determines the affinity of binding to βγ subunits of heterotrimeric guanine-nucleotide-binding regulatory proteins.  European Journal of Biochemistry.  1997
  • Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component.  Journal of Biological Chemistry.  1997
  • Prion protein fragment 106-126 differentially induces heme oxygenase-1 mRNA in cultured neurons and astroglial cells.  Journal of neurochemistry.  1997
  • Spectroscopic and binding studies on the interaction of inorganic anions with lactoperoxidase.  Journal of Inorganic Biochemistry.  1997
  • [[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT(1A) receptor ligands.  Journal of Medicinal Chemistry.  1997
  • p21(WAF1)-derived peptides linked to an internalization peptide inhibit human cancer cell growth.  Cancer Research.  1997
  • A theoretical three-dimensional model for lactoperoxidase and eosinophil peroxidase, built on the scaffold of the myeioperoxidase X-ray structure.  Journal of Biological Inorganic Chemistry.  1996
  • Activation effects of a prion protein fragment [PrP-(106-126)] on human leucocytes.  Biochemical Journal.  1996
  • Amino terminal region of acute phase, but not constitutive, serum amyloid A (apoSAA) specifically binds and transports cholesterol into aortic smooth muscle and HepG2 cells.  Journal of Lipid Research.  1996
  • Amyloid in Alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides.  Progress in Neurobiology.  1996
  • Apoptosis-mediated neurotoxicity induced by β-amyloid and PRP fragments.  Molecular and Chemical Neuropathology.  1996
  • Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.  Blood.  1996
  • Clusterin (SGP-2) induction in rat astroglial cells exposed to prion protein fragment 106-126.  European Journal of Neuroscience.  1996
  • Effect of subchronic in vivo exposure to nitrogen dioxide on lung tissue inflammation, airway microvascular leakage, and in vitro bronchial muscle responsiveness in rats.  Occupational and Environmental Medicine.  1996
  • In vivo exposure to NO2 reduces TNF and IL-6 production by endotoxin- stimulated alveolar macrophages.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  1996
  • In vivo exposure to NO2 reduces TNF and IL-6 production by endotoxin-stimulated alveolar macrophages.  American Journal of Physiology.  1996
  • Intracellular calcium rise through L-type calcium channels, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation.  Biochemical and Biophysical Research Communications.  1996
  • Placental transfer of valproic acid after liposome encapsulation during in vitro human placenta perfusion.  Journal of Pharmacology and Experimental Therapeutics.  1996
  • Potentials of liposomes in diagnosis and treatment of pulmonary metastases: An experimental study in the rat.  European Journal of Cardio-thoracic Surgery.  1996
  • Spontaneous spongiform encephalopathy in a young adult rhesus monkey.  Comptes Rendus de l'Academie des Sciences - Serie III.  1996
  • β25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells.  Journal of neurochemistry.  1996
  • βPP and tau interaction: A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.  American Journal of Pathology.  1996
  • Basic proteins and basic membranes adjusting blotting and staining conditions to immobilon CD.  Journal of Chromatography A.  1995
  • Extracellular glutamate levels in the hypothalamus and hippocampus of rats after acute or chronic oral intake of monosodium glutamate.  Neuroscience Letters.  1995
  • Fate of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET18-OMe) in malignant cells, normal cells, and isolated and perfused rat liver.  Drug Metabolism and Disposition.  1995
  • Intraluminal inflammation in the airways of patients with chronic bronchitis after treatment with Ambroxol.  Monaldi Archives for Chest Disease.  1995
  • Manganese Peroxidase from Phanerochaete chrysosporium A Homology‐Based Molecular Model.  European Journal of Biochemistry.  1995
  • Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes.  Journal of Biological Chemistry.  1995
  • Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase.  Journal of Biological Chemistry.  1995
  • Reye's and reye-like syndromes, drug-related diseases? (causative agents, etiology, pathogenesis, and therapeutic approaches).  Drug Metabolism Reviews.  1995
  • The imbalance of brain large-chain aminoacid availability in amyotrophic lateral sclerosis patients treated with high doses of branched-chain aminoacids.  Neurochemistry International.  1995
  • A Neurotoxic Prion Protein Fragment Induces Rat Astroglial Proliferation and Hypertrophy.  European Journal of Neuroscience.  1994
  • An automated system for animal exposure to nitrogen dioxide.  Journal of Pharmacological and Toxicological Methods.  1994
  • Biochemical effects of acute and subacute nitrogen dioxide exposure in rat lung and bronchoalveolar lavage fluid.  Archives of Environmental Contamination and Toxicology.  1994
  • Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein.  Journal of Biological Chemistry.  1994
  • In vivo anti‐tumor activity of synthetic ether lipids is not enhanced by pharmacological modulation of tumor lipid composition.  International Journal of Cancer.  1994
  • Molybdenum(VI) salts convert the xanthine oxidoreductase apoprotein into the active enzyme in mouse L929 fibroblastic cells.  Biochemical Journal.  1994
  • Solubilization and characterization of d-fenfluramine binding sites from bovine cerebral cortex.  Life Sciences.  1994
  • The induction of apoptosis is a common feature of the cytotoxic action of ether‐linked glycerophospholipids in human leukemic cells.  International Journal of Cancer.  1994
  • The purification of histones by metal-chelate chromatography.  Analytical Biochemistry.  1994
  • Analytical validity of electrochemical determination of lecithin for establishing foetal lung maturity in normal and complicated pregnancies.  Monaldi Archives for Chest Disease.  1993
  • Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35.  NeuroReport.  1993
  • Defective glomerular [³H]lysoPAF metabolism in the autologous phase of rabbit nephrotoxic nephritis.  Kidney International.  1993
  • Effect of PAF antagonists on the cytotoxic activity of anti-neoplastic ether phospholipids.  International Journal of Oncology.  1993
  • Effect of cell density on cytotoxicity of ether lipid analogues in variants of B16 murine melanoma.  Lipids.  1993
  • Fetal lung maturity evaluation with fluorescence polarization of the amniotic fluid.  Journal of Perinatal Medicine.  1993
  • Induction of apoptosis in human leukemic cells by the ether lipid 1‐octadecyl‐2‐methyl‐RAC‐glycero‐3‐ phosphocholine. A possible basis for its selective action.  International Journal of Cancer.  1993
  • Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein.  Biochemical and Biophysical Research Communications.  1993
  • Neurotoxicity of a prion protein fragment.  Nature.  1993
  • Protein kinase C is not involved in cholesterol-induced resistance to synthetic ether lipids.  ANTICANCER RESEARCH.  1993
  • Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.  Proceedings of the National Academy of Sciences of the United States of America.  1993
  • The effect of culture medium composition on ether lipid cytotoxic activity.  Lipids.  1993
  • The pneumotoxicant paraquat induces IL-8 mRNA in human mononuclear cells and pulmonary epithelial cells.  Cytokine.  1993
  • A novel pharmacological approach for paraquat poisoning in rat and A549 cell line using ambroxol, a lung surfactant synthesis inducer.  Food and Chemical Toxicology.  1992
  • A soluble form of prion protein in human cerebrospinal fluid: Implications for prion-related encephalopathies.  Biochemical and Biophysical Research Communications.  1992
  • Effect of L-carnitine and L-acetyl-carnitine on an animal model of reye syndrome.  Pharmacological Research.  1992
  • Effect of ambroxol on rabbit eustachian tube surfactant.  ORL.  1992
  • Modulation of ATPase activity by cholesterol and synthetic ether lipids in leukemic cells.  Biochemical Pharmacology.  1992
  • Phospholipid composition, phosphoinositide metabolism and metastatic capacity in murine melanoma B16 variants at different stages of growth.  Melanoma Research.  1992
  • Role of surfactant in chronic obstructive pulmonary disease: Therapeutic implications.  Respiration.  1992
  • Synthetic ether lipids fluidizing action and cell membrane lipid composition: A commentary note.  International Journal of Cancer.  1992
  • Aging and food restriction: Effect on lipids of cerebral cortex.  Neurobiology of Aging.  1991
  • Effect of hypothyroidism induced in adult rats on brain membrane fluidity and lipid content and composition.  Research Communications in Chemical Pathology and Pharmacology.  1991
  • Effect of iodinated contrast media on the synthesis and metabolism of leukotriene B4.  Investigative Radiology.  1991
  • Effect of tyrosine on the potentiation by aspartame and phenylalanine of metrazol-induced convulsions in rats.  Food and Chemical Toxicology.  1991
  • Increased ether lipid cytotoxicity by reducing membrane cholesterol content.  International Journal of Cancer.  1991
  • Interspecies and interstrain studies on the increased susceptibility to metrazol-induced convulsions in animals given aspartame.  Food and Chemical Toxicology.  1991
  • Protection against acute paraquat toxicity by ambroxol.  Cytotechnology.  1991
  • Alpha-1-antitrypsin variants produced by recombinant DNA: differences in elastase inhibitory activity and resistance to oxidant agents.  International Journal of Tissue Reactions.  1990
  • Determination of argininosuccinate lyase and arginase activities with an amino acid analyzer.  Analytical Biochemistry.  1990
  • Disaturated phosphatidylcholine in rabbit eustachian tube surfactant.  ORL.  1990
  • Effect of ambroxol on surfactant of rabbit eustachian tube.  European Journal of Pharmacology.  1990
  • Effect of iodinated contrast media on the synthesis and metabolism of leukotriene B4.  Investigative Radiology.  1990
  • Fluorescence polarization changes with gestational age in amniotic fluid of rabbit and Guinea pig.  Experimental Lung Research.  1990
  • Interferon inducers increase o-alkylguanine-dna alkyltransferase in the rat liver.  Carcinogenesis.  1990
  • Oral zeranol shortens the prolonged bleeding time of uremic rats.  Kidney International.  1990
  • Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame.  Food and Chemical Toxicology.  1990
  • Role of cell cholesterol in modulating antineoplastic ether lipid uptake, membrane effects and cytotoxicity.  International Journal of Cancer.  1990
  • Effects of aspartame and carbohydrate administration on human and rat plasma large neutral amino acid levels and rat brain amino acid and monoamine levels.  Journal of Nutrition.  1989
  • Membrane fluidity affects tumor-cell motility, invasion and lung-colonizing potential.  International Journal of Cancer.  1989
  • Relationship between changes in alveolar surfactant levels and lung defence mechanisms.  Respiration.  1989
  • A rapid electrochemical assay of lecithin in amniotic fluid using a fluoride ion-sensitive electrode.  Clinica Chimica Acta.  1988
  • Aspartame and the rat brain monoaminergic system.  Toxicology Letters.  1988
  • Clinical assessment of fetal lung maturity in high risk pregnancies using fluorescence polarization.  Journal of Perinatal Medicine.  1988
  • Differential effects of benzodiazepines on phospholipid methylation in hippocampus and cerebellum of rats.  Life Sciences.  1988
  • Effect of aspartame on seizures in various models of experimental epilepsy.  Toxicology and Applied Pharmacology.  1988
  • In vivo studies of rat alveolar macrophage microviscosity: Influence of pulmonary surfactant synthesis stimulation.  Lung.  1988
  • Interaction of the anticonvulsants, denzimol and nafimidone, with liver cytochrome P450 in the rat.  Journal of Pharmacy and Pharmacology.  1988
  • Liver DNA alkylation after a single carcinogenic dose of dimethylnitrosamine to newborn and adult CFW Swiss mice.  Chemico-Biological Interactions.  1988
  • Rapid internalization of benzodiazepine receptors in the rat cortex induced by handling..  Advances in biochemical psychopharmacology.  1988
  • DNA synthesis, mitotic index, drug-metabolising systems and cytogenetic analysis in regenerating rat liver. Comparison with bone marrow test after 'in vivo' treatment with cyclophosphamide.  Mutation Research/Environmental Mutagenesis and Related Subjects.  1987
  • Defective production of reactive oxygen intermediates by tumor-associated macrophages exposed to phorbol ester.  Journal of Leukocyte Biology.  1987
  • Fluorescence polarization for measuring the production of surfactant in pathological pregnancies | La polarizzazione a fluorescenza per la misurazione della produzione di surfattante in gravidanze patologiche..  Annali di ostetricia, ginecologia, medicina perinatale.  1987
  • In vivo studies of rat alveolar macrophase microviscosity: Influence of pulmonary surfactant synthesis stimulation.  Lung.  1987
  • Incorporation of labeled phospholipids in Eustachian tube surfactant | Incorporazione di fosfolipidi marcati nel surfattante tubarico..  Acta Otorhinolaryngologica Italica.  1987
  • Measurement of fetal surfactant production by fluorescence polarization of amniotic fluid in complicated pregnancies.  Clinica Chimica Acta.  1987
  • Pharmacologic stimulation of surfactant at the pulmonary level | Stimolazione farmacologica del surfattante a livello polmonare..  Acta Otorhinolaryngologica Italica.  1987
  • Role of alveolar phospholipids in bleomycin-induced pulmonary fibrosis in the rat.  Respiration.  1987
  • Ambroxol and pulmonary toxicity induced by antineoplastic drugs.  International Journal of Clinical Pharmacology Research.  1986
  • Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter.  Toxicology and Applied Pharmacology.  1986
  • Determination of fetal lung maturity in rats by fluorescence polarization.  Biochemical Pharmacology.  1986
  • Gentisic acid: an aspirin metabolite with multiple effects on human blood polymorphonuclear leukocytes.  Biochemical Pharmacology.  1986
  • N-acetyl-β-d-glucosaminidase (NAG) levels in amniotic fluid or urine in prenatal and postnatal life.  Early Human Development.  1986
  • The rate of n-demethylation of n,n-dimethylanilines and n-methylanilines by rat-liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor.  Xenobiotica.  1986
  • Correlation between newborn gastric aspirate microviscosity and gestational age.  Acta Obstetricia et Gynecologica Scandinavica.  1985
  • Intact human lymphocyte membranes respond to muscarinic receptor stimulation by oxotremorine with marked changes in microviscosity and an increase in cyclic GMP.  FEBS Letters.  1985
  • Kinetics of monosodium glutamate in human volunteers under different experimental conditions.  Food and Chemical Toxicology.  1985
  • Perinatal development of cytochrome P-450, cytochrome C reductase, aryl hydrocarbon hydroxylase, styrene monooxygenase, and styrene epoxide hydrolase in rabbit liver microsomes and nuclei.  Developmental Pharmacology and Therapeutics.  1985
  • Platelet derived growth factor induces ornithine decarboxylase activity in nih 3T3 cells.  Biochemical and Biophysical Research Communications.  1985
  • Prostaglandins and aminoglycoside nephrotoxicity.  Toxicology and Applied Pharmacology.  1985
  • Role of Reactive Oxygen Intermediates in the Interferon-mediated Depression of Hepatic Drug Metabolism and Protective Effect of N-Acetylcysteine in Mice.  Cancer Research.  1985
  • Tumor-derived chemotactic factor(s) from human ovarian carcinoma: Evidence for a role in the regulation of macrophage content of neoplastic tissues.  International Journal of Cancer.  1985
  • Characterization of arachidonic acid metabolic profiles in animal tissues by high-resolution gas chromatography-mass spectrometry.  Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism.  1984
  • Diazepam increases membrane fluidity of rat hippocampus synaptosomes.  FEBS Letters.  1984
  • Different susceptibility of mouse tissues to porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin.  Toxicology Letters.  1984
  • Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers.  Biochemical and Biophysical Research Communications.  1984
  • Kinetics of 3-tert-butyl-4-hydroxyanisole (BHA) in man.  Food and Chemical Toxicology.  1984
  • Prostaglandin Endoperoxide Synthetase and the Activation of Benzo(a)pyrene to Reactive Metabolites in Vivo in Guinea Pigs.  Cancer Research.  1984
  • Structure reactivity relationships in the microsomal oxidation of tertiary amines.  European Journal of Drug Metabolism and Pharmacokinetics.  1984
  • Chemotactic activity for mononuclear phagocytes of culture supernatants from murine and human tumor cells: Evidence for a role in the regulation of the macrophage content of neoplastic tissues.  International Journal of Cancer.  1983
  • Dissociation between macrophage tumoricidal capacity and suppressive activity: Analysis with macrophage-defective mouse strains.  Journal of Immunology.  1983
  • Evaluation of epichlorohydrin (ECH) genotoxicity. Microsomal epoxide hydrolase-dependent deactivation of ECH mutagenicity in Schizosaccharomyces pombe in vitro.  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  1983
  • Interferon decreases production of hydrogen peroxide by macrophages: Correlation with reduction of suppressive capacity and of anti-microbial activity.  Immunology.  1983
  • Is there a role for nuclei in the metabolism of xenobiotica? a review.  Drug Metabolism Reviews.  1983
  • Mutagenic relevance of rat hepatocyte nuclei in the activation and inactivation of xenobiotica cyclophosphamide and epichlorohydrin activity on the yeasts S. pombe and S. cerevisiae.  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  1983
  • N-Acetyl-β-d-glucosaminidase (NAG) and NAG isoenzymes in children with upper and lower urinary tract infections.  Clinica Chimica Acta.  1983
  • Nuclear drug metabolism: its ontogeny in the rat and its presence in human fetal life..  Progress in clinical and biological research.  1983
  • Perinatal development of styrene monooxygenase and epoxide hydrolase in rat liver microsomes and nuclei.  Chemico-Biological Interactions.  1983
  • Plasma pyroglutamic acid levels after oral administration of monosodium glutamate to human volunteers.  Toxicology Letters.  1983
  • Pyroglutamate kinetics and neurotoxicity studies in mice.  Toxicology Letters.  1983
  • Regulation of the macrophage content of neoplasms by chemoattractants.  science.  1983
  • Styrene oxidation to styrene oxide in human erythrocytes is catalyzed by oxyhemoglobin.  Experientia.  1983
  • The influence of selenium intake on chronic adriamycin toxicity and lipid peroxidation in rats.  Toxicology Letters.  1983
  • Toxicological evaluation of urban waste incinerator emissions.  Chemosphere.  1983
  • Determination of dipeptides in protein hydrolysates for total parenteral nutrition.  Journal of Chromatography A.  1982
  • Further studies on adriamycin induced in vitro lipid peroxidation.  Chemico-Biological Interactions.  1982
  • IFN-β-induced reduction of superoxide anion generation by macrophages.  Immunology.  1982
  • Perinatal development of cytochrome P-450, nadphcytochrome c reductase and ethoxycoumarin deethylase in rat liver nuclear membranes.  Chemico-Biological Interactions.  1982
  • Regulation of macrophage functions by interferon..  Advances in Experimental Medicine and Biology.  1982
  • Urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) by children with upper or lower urinary tract infections.  Acta Paediatrica Scandinavica.  1982
  • GLC-Mass fragmentographic determination of saccharin in biological fluids.  Journal of Pharmaceutical Sciences.  1981
  • Induction of mixed-function oxidase by chronic treatment with 2,3,7,8-tetrachloro-dibenzo-p-dioxin in female rats.  Toxicology.  1981
  • Induction of nuclear styrene monooxygenase and epoxide hydrolase in rat liver.  Experientia.  1981
  • Methodological and clinical aspects of urinary N-acetyl-glucosaminidase in pediatric subjects.  Biochemical medicine.  1981
  • Nuclear metabolism. II. Further studies on epoxide hydrolase activity.  Chemico-Biological Interactions.  1981
  • Plasma kinetics and urinary elimination of saccharin in man.  Toxicology Letters.  1981
  • Porphyrogenic effect of chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats. Dose-effect relationship following urinary excretion of porphyrins.  Toxicology and Applied Pharmacology.  1981
  • Effect of oral monosodium glutamate on glutamic acid levels in the nucleus arcuatus of the hypothalamus and on serum osmolality of adult and infant mice.  Toxicology Letters.  1980
  • Effects of chronic treatment with DI-(2-ethylhexyl) phthalate on rat liver microsomal activities.  Toxicology Letters.  1980
  • Improved gas chromatographic method for measuring phenylethylene glycol. Application to the determination of styrene monooxygenase and epoxide hydrase activities.  Journal of Chromatography A.  1980
  • In vitro effects of saccharin on cell-mediated host defence mechanisms.  Toxicology Letters.  1980
  • Is nuclear styrene monooxygenase activity a microsomal artifact?.  Chemico-Biological Interactions.  1980
  • Monosodium glutamate kinetic studies in human volunteers.  Toxicology Letters.  1980
  • Non-linear kinetics of microsomal styrene monooxygenase after phenobarbital pre-treatment.  Experientia.  1980
  • Nuclear metabolism. I. Determination of styrene monooxygenase activity in rat liver nuclei.  Chemico-Biological Interactions.  1980
  • Plasma glutamic acid levels in premature newborn.  Toxicology Letters.  1980
  • Possible relevance of N-trifluoroacetyladriamycin (AD 41) in the antitumoral activity of N-trifluoroacetyladriamycin-14 (AD 32) in tumor-bearing mice. I. Pharmacokinetic evidence.  Cancer Treatment Reports.  1980
  • Decreased half life of cyclophosphamide in patients under continual treatment.  European Journal of Cancer (1965).  1979
  • Esterase activity of rat muscle.  European Journal of Drug Metabolism and Pharmacokinetics.  1979
  • Ftorafur: A self-limiting source of 5-fluorouracil?.  Cancer Chemotherapy and Pharmacology.  1979
  • Glutamic acid and sodium levels in the nucleus arcuatus of the hypothalamus of adult and infant rats after oral monosodium glutamate.  Toxicology Letters.  1979
  • Isolation and structure determination of enzymatically formed styrene oxide glutathione conjugates.  Chemico-Biological Interactions.  1979
  • Quantitative gas-liquid chromatographic determination of ftorafur and 5-fluorouracil in biological specimens.  Analytical Biochemistry.  1979
  • Quantitative thin-layer chromatographic measurement of N-trifluoroacetyladriamycin-14-valerate (AD 32) and trifluoroacetyladriamycin (AD 41) in blood and tissues.  Journal of Chromatography B: Biomedical Sciences and Applications.  1979
  • Arene oxides in styrene metabolism, a new perspective in styrene toxicity?.  Scandinavian Journal of Work, Environment and Health.  1978
  • Degradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin in organic solvents by gamma ray irradiation.  Experientia.  1978
  • Hepatic and extrahepatic formation and hydration of styrene oxide in vitro in animals of different species and sex.  Toxicology Letters.  1978
  • Intercalation with DNA is a prerequisite for Daunomycin, Adriamycin and its congeners in inhibiting DNAase I.  Chemico-Biological Interactions.  1978
  • Serum glutamate in rhesus macaques after gavage with MSG.  Toxicology Letters.  1978
  • Simple and sensitive method for the determination of cyclophosphamide by means of a nitrogen-phosphorus-selective detector.  Journal of Chromatography B: Biomedical Sciences and Applications.  1978
  • The absorption by human volunteers of glutamic acid from monosodium glutamate and from a partial enzymic hydrolysate of casein.  Toxicology.  1978
  • The oral administration of msg at varying concentrations to male mice.  Toxicology Letters.  1978
  • Uptake of glutamate in beagle dogs after oral gavage with MSG.  Toxicology Letters.  1978
  • Effect of daunomycin, adriamycin and its congener AD 32 on the activity of DNase I from bovine pancreas.  Biochemical Pharmacology.  1977
  • In vitro binding and metabolism of iopronic acid by rat liver microsomes.  Pharmacological Research Communications.  1977
  • Inhibition of liver microsomal epoxide hydrase by cyproheptadine epoxide.  Experientia.  1977
  • Kinetic behaviour of microsomal styrene monooxygenase and styrene epoxide hydratase in different animal species.  Experientia.  1977
  • Kinetics of monosodium glutamate in relation to its neurotoxicity.  Toxicology Letters.  1977
  • A specific gas chromatographic method for the determination of microsomal styrene monooxygenase and styrene epoxide hydratase activities.  Journal of Chromatography A.  1976
  • Activity of liver microsomal mono-oxygenases on some epoxide-forming tricyclic drugs. I. Kinetics in vitro.  Xenobiotica.  1976
  • Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.  Xenobiotica.  1976
  • Uptake of ¹⁴C-5-hydroxytryptamine by human and rat platelets and its pharmacological inhibition - A comparative kinetic analysis.  Naunyn-Schmiedeberg's Archives of Pharmacology.  1976
  • Gas chromatographic-mass spectrometric determination of intact C3-hydroxylated benzodiazepine glucuronides in urine.  Journal of Chromatography A.  1975
  • Relationship of in vitro hydrolysis of 17 chloroacetylajmaline and 17 acetylajmaline in different animal species.  Journal of Pharmaceutical Sciences.  1975
  • In vitro hydrolysis of oxazepam succinate half ester by a stereospecific soluble esterase from different animal species.  Journal of Pharmaceutical Sciences.  1974

• documento

  • Food-Grade Titanium Dioxide Induces Toxicity in C. elegans and Acute Hepatic and Pulmonary Response in Mice

• documento de conferencia

  • Nanoparticles for therapy of Alzheimer Disease.  Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. 2013
  • Nano-liposomes targeting Abeta peptide and functionalized to interact with the blood-brain barrier.  24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials. 2011

• libro

  • Brain Dysfunction Associated with Amyloid Fibrils and Other Aggregated Proteins 2008
  • Hereditary prion protein amyloidoses 2005